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Research ProgramStructural Biology
Research Interests
(Chair, Chemistry): Theoretical Biophysical Chemistry. Electrostatic properties and their contribution to the regulation of nucleic acid structure and function.
Our group is interested in theoretical and computational biophysical chemistry. We have been developing and applying computational methods to the study of the properties of DNA. Electrostatic forces are particularly important in determining nucleic acid structure and function and the application of the Poisson-Boltzmann equation and Monte Carlo techniques have allowed us to describe the distribution of monovalent and divalent electrolyte ions around these polyelectrolytes. We have been developing better theoretical descriptions of the dielectric properties of the DNA-electrolyte systems in order to increase the accuracy of computational approaches. Current efforts are directed toward understanding metal-catalyzed splicing of DNA strands, and the interactions of magnesium ions with catalytic RNAs.
EducationEducation/Training
B.S., Providence College, Rhode Island, Mathematics, 1968
Ph.D., State University of New York, Buffalo, New York, Biophysics, 1973
Postdoc, University of Rochester, New York, Chemistry, 1973-1974
Postdoc, New York University, New York, Environmental Medicine, 1974-1975
Postdoc, Stanford University, California, Genetics, 1975-1978
Research and Professional Experience
1978-1983
Assistant Professor, Biophysics, University of Illinois, College of Medicine, Rockford, Illinois
1983-1988
Associate Professor, Biophysics, University of Illinois, College of Medicine, Rockford, Illinois
1985-1986
Research Biophysical Chemist, Laboratory of Chemical Physics, NIADDK, National Institutes of Health, Bethesda, Maryland
1988-1998
Professor, Biophysics, University of Illinois, College of Medicine, Rockford, Illinois
1998-present
Professor, Dept. of Chemistry, University of Louisville, Louisville, Kentucky
2001-present
Senior Scientist, James Graham Brown Cancer Center, University of Louisville
Selected Awards and Professional Honors
1973
Ph.D awarded with distinction
1984-1986
Special Member, National Institutes of Health, BBCA Study Section
1996-2000
Secretary/Treasurer, International Society of Quantum Biology and Pharmacology
PublicationsMagnuson E, Lamm G, Koehler J, Pack GR. Cation-DNA recognition: the contribution of Mg(H2O)6-P interactions. J Phys Chem 106:3294-3300, 2002
Petrov A, Lamm G, Pack GR. Water-mediated magnesium-guanine interactions. J Phys Chem 106:3294-3300, 2002
Lamm G, Pack GR. Induced coalescence of cations through low-temperature Poisson-Boltzmann calculations. Biophys J 87(2):764-7, 2004
Petrov AS, Lamm G, Pack GR. The triplex-hairpin transition in cytosine-rich DNA. Biophys J 87(6):3954-73, 2004
Petrov AS, Lamm G, Pack GR. Calculation of the binding free energy for magnesium-RNA interactions. Biopolymers 77(3):137-54, 2005
Rakitin AR, Pack GR. Necessity of aromatic carboxylate anions to be planar to induce growth of cationic micelles. Langmuir 21(3):837-40, 2005
Phone: Coming soon.
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