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Professor of Biochemistry; Senior Scientist, James Graham Brown Cancer Center
Research ProgramStructural Biology
Research Interests
Protein-protein interactions of membrane-associated proteins.
My research interests are in the analysis of macromolecular interactions involved in regulation of transport protein function with emphasis on transport ATPases using detergent solubilization and analytical ultracentrifugation along with other biophysical and biochemical approaches.
Education
B.S., Yale University, New Haven, CT, Biology/Biochemistry, 1968-1972
Ph.D., University of Michigan, Ann Arbor, MI, Biochemistry, 1972-1976
Post-Doc, Duke University, Durham, NC, Physical Biochemistry, 1976-1979
Research and Professional Experience
1979-1984
Assistant Professor of Biochemistry, University of Louisville
1984-1989
Associate Professor of Biochemistry, University of Louisville
1989-present
Professor of Biochemistry, University of Louisville
1994-2000
Associate, Center for Applied Microcirculatory Research, University of Louisville
2003-present
Member, James Graham Brown Cancer Center, University of Louisville
Selected Awards and Professional Honors
1968
Allied Chemical Scholarship
1971
Yale University Academic Scholarship
1972
Graduated from Yale University Magna cum Laude, Phi Beta Kappa and high honors in biology
1992-present Member of the Board of the European Platelet Group
1996-1997 Chairman, Peer Review Group of the Kentucky Affiliate of the American Heart Association
1997-2000 Member of the Ohio Valley Research Committee and Peer Review Committee, American Heart Association
2002-present Member of Ohio Valley Consortium Peer Review committee
Publications
Blankenship KA, Dawson CB, Aronoff GR, Dean WL. Tyrosine phosphorylation of human platelet plasma membrane Ca2+-ATPase. Hypertension 35:103-7, 2000
Zabe M, Dean WL. Plasma membrane Ca2+-ATPase associates with the cytoskeleton in activiated platelets through a PDZ binding domain. J Biol Chem 276:14704-9, 2001
Wan TC, Zabe M, Dean WL. Plasma membrane Ca2+-ATPase isoform 4b is phosphorylated on tyrosine 1176 in activated human platelets. Thromb Haemost 89:122-31, 2003
Inoue O, Suzuki-Inoue K, Dean WL, Frampton J, Watson SP. Integrin a2b1 mediates outside-in regulation of platelet spreading on collagen through activion of Src kinases and plcg2. Cell Biol 160:769-80, 2003
Powell DW, Rane MJ, Joughin BA, Kalmukova R, Hong JH, Tidor B, Dean WL, Pierce WM, Klein JB, Yaffe MB, McLeish KR. Proteomic identification of 14-3-3z as a MAPK-activated protein kinase-2 substrate: Role in dimer formation and ligand binding. Mol Cell Biol 23:5376-87, 2003
Schraw TD, Lemons PP, Dean WL, Whiteheart SW. A role for Sec 1/Munc18 proteins in platelet exocytosis. Biochem J 374:207-17, 2003
Dean WL, Whiteheart SW. Plasma membrane Ca2+-ATPase (PMCA) translocates to filopodia during platelet activation. Thromb Haemost 91:325-33, 2004
Bozulic LD, Dean WL, Delamere NA. The influence of protein tyrosine phosphatase-1B on Na,K-ATPase activity in lens. J Cell Physiol 200(3):370-6, 2004.
Bozulic LD, Dean WL, Delamere NA. The influence of SRC-family tyrosine kinases on Na,K-ATPase activity in lens epithelium. Invest Ophthalmol Vis Sci 46(2):618-22, 2005.
Khundmiri SJ, Dean WL, McLeish KR, Lederer ED. Parathyroid hormone-mediated regulation of Na+-K+-ATPase requires ERK-dependent translocation of protein kinase Calpha. J Biol Chem 280(10):8705-13, 2005.
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