Publications
Cunningham AR, Klopman G, Rosenkranz HS. The carcinogenicity of diethylstilbestrol: structural evidence for a non-genotoxic mechanism. Arch Toxicol 70:356-61, 1996.
Cunningham AR, Klopman G, Rosenkranz HS. A study of the structural basis of the carcinogenicity of tamoxifen toremifene and their metabolites. Mutation Res 349:85-94, 1996.
Rosenkranz HS, Cunningham A, Klopman G. Identification of a 2-D geometric descriptor associated with non-genotoxic carcinogens and some estrogens and antiestrogens. Mutagenesis 11:95-100, 1996.
Rosenkranz HS, Liu M, Cunningham AR, Klopman G. Application of structural concepts to evaluate the potential carcinogenicity of natural products. SAR QSAR Environ Res 5:79-98, 1996.
Cunningham AR, Klopman G, Rosenkranz HS. A dichotomy in the lipophilicity of natural estrogens/ xenoestrogens and phytoestrogens. Environ Health Perspectives Supplements 105(Suppl3):665-8, 1997.
Cunningham AR, Rosenkranz HS, Zhang YP, Klopman G. Identification of "genotoxic" and "non-genotoxic" alerts for cancer in mice: The carcinogenic potency database. Mutation Res 398:1-17, 1998.
Cunningham AR, Rosenkranz HS, Klopman G. Identification of structural features and associated mechanisms of action for carcinogens in rats. Mutation Res 405:9-28, 1998.
Cunningham AR, Rosenkranz HS, Klopman G. Structural analysis of a group of phytoestrogens for the presence of a 2-D geometric descriptor associated with non-genotoxic carcinogens and some estrogens. Proc Soc Exp Biol Med 217:288-92, 1998.
Pollack N, Cunningham AR, Klopman G, Rosenkranz HS. Chemical diversity approach for evaluating mechanistic relatedness among toxicological phenomena. SAR QSAR Environ Res 10:533-43, 1999.
Rosenkranz HR, Cunningham AR, Zhang YP, Klopman G. Applications of the CASE/MULTICASE SAR method to environmental and public health situations. SAR QSAR Environ Res 10:263-76, 1999.
Rosenkranz HS, Cunningham AR, Zhang YP, Claycamp HG, Macina OT, Sussman NB, Grant SG, Klopman G. Development, characterization and application of predictive-toxicology models. SAR QSAR Environ Res 10:277-98, 1999.
Rosenkranz HS, Cunningham AR. The High Production Volume Chemical Challenge Program: The relevance of the in vivo micronucleus assay. Regula Toxicol Pharmacol 31:182-9, 2000.
Rosenkranz HS, Cunningham AR. The High Production Volume Chemical Challenge Program: The rodent LD50 and its possible replacement. Alternatives Lab Animals 28:271-7, 2000.
Rosenkranz HS, Pollack N, Cunningham AR. Exploring the relationship between inhibition of gap junctional intracellular communication and other biological phenomena. Carcinogenesis 21:1007-11, 2000.
Rosenkranz HS, Cunningham AR. A new approach to evaluate mechanistic relationships among genotoxic phenomena: Validation. Mutagenesis 15:325-8, 2000 .
Rosenkranz HS, Cunningham AR. A battery of cell toxicity assays as predictors of eye irritation: A feasibility study. Alternatives Lab Animals 28:603-7, 2000.
Rosenkranz HS, Cunningham AR. SAR modeling of genotoxic phenomena: The effect of supplementation with physiological chemicals. Mutation Res 476:133-7, 2000.
Cunningham AR, Rosenkranz HS. Estimating the extent of health hazard posed by high production volume chemicals. Environmental Health Perspectives 109:953-6, 2001.
Karol MH, Macina OT, Cunningham AR. Cell and molecular biology of chemical allergy. Annals Allergy Asthma Immunol 87:28-32, 2001.
Rosenkranz HS, Cunningham AR. Chemical categories for health hazard identification: A feasibility study. Regula Toxicol Pharmacol 33:313-318(2001).
Rosenkranz HS, Cunningham AR. Prevalence of mutagens in the environment: Experimental data vs. simulation. Mutation Res 484:49-51, 2001.
Rosenkranz HS, Cunningham AR. SAR modeling of unbalanced data sets. SAR QSAR Environ Res 12:267-74, 2001.
Cunningham AR, Cunningham SL, Day BW. Identification of structural components associated with cytostatic activity in MCF-7 but not in MDA-MB-231 cells. Bioorganic Medicinal Chem 11:5249-58, 2003.
Pollack N, Cunningham AR, Rosenkranz HR. Environmental persistence of chemicals and their carcinogenic risk to humans. Mutation Res 528:81-91, 2003.
Rosenkranz HS, Cunningham AR. Environmental odors and health hazards. Sci Total Environ 313:15-24, 2003.
Rosenkranz HS, Cunningham AR. Environmental persistence of chemicals and their carcinogenic risk to humans. Mutation Res 528:81-91, 2003.
Rosenkranz HR, Cunningham AR. A substructure-based SAR model for odor perception in humans relevant to health risk assessment. SAR QSAR Environ Res 14:215-22, 2003.
Vanoirbeek JAJ, Mandervelt C, Cunningham AR, Hoet PHM, Hadewijch HX, Vanhooren HM, Nemery B. Validity of methods to predict the respiratory sensitising potential of chemicals. A study with a piperidinyl chlorotriazine derivative that caused an outbreak of occupational asthma. Toxicol Sci 76:338-46, 2003.
Cunningham AR, Cunningham SL, Rosenkranz HR. Structure activity approach to the identification of environmental estrogens: The MCASE approach. SAR QSAR Environ Res 15:55-67, 2004.
Cunningham AR, Cunningham SL, Consoer DM, Moss ST, Karol MH. Development of an information-intensive structure- activity relationship model and its application to human respiratory chemical sensitizers. SAR QSAR Environ Res 16:273-85, 2005.
Cunningham SL, Cunningham AR, Day BW. CoMFA, HQSAR and molecular docking studies of butitaxel analogues with ß-tubulin. J Molec Model 11:48-54, 2005.
Rosenkranz HR, Cunningham AR. Lack of predictivity of the rat lethality (LD50) test for ecological and human health effects. Alternatives Lab Animals 33:9-19, 2005.
Rosenkranz HS, Cunningham SL, Mermelstein R, Cunningham AR. The challenge of testing chemicals for potential carcinogenicity using multiple short term assays. An analysis of a proposed test battery for hair dyes. Mutation Res (in press).