Zafrulla Khan, D.D.S., M.S.

Director of Dental Oncology/Maxillofacial Prosthetics, James Graham Brown Cancer Center

Professor, Prosthodontics, School of Dentistry

Associate, Departments of Medicine & Radiation Oncology, School Of Medicine

Multidisciplinary Clinic
Head & Neck

Research Program
Prevention & Control

Clinical Expertise
Dental Oncology
Head and Neck

Education
D.D.S., Bangalore University, Dentistry, 1967-1972

Certificate, State University of New York, Buffalo, Removable Prosthodontics, 1977-1978

Certificate, University of Texas, MD Anderson Cancer Center, Maxillofacial Prosthetics/Oncology, 1987-1988

M.S., University of Louisville, Oral Biology, 1993-1995

Research and Professional Experience

1977-1979
Assistant Professor,
Erie Community College

1977-1979
Clinical Instructor,
State University of New York at Buffalo Dental School

1979-1985
Assistant Professor,
University of Louisville School of Dentistry, Louisville, KY

1984-1989
Director, Advanced Education Program in Prosthodontics,
University of Louisville

1985-1990
Associate Professor, Department of Prosthodontics,
University of Louisville

1989-1992
Acting Chairman, Department of Reconstructive Dentistry,
University of Louisville

1989-present
Director, Dental Oncology/Maxillofacial Prosthetics, James Graham Brown Cancer Center,
University of Louisville

1990-present
Professor, Department of Prosthodontics,
University of Louisville Dental School

1991-present
Associate in Medicine,
University of Louisville School of Medicine

1992-1998
Chairman, Department of Prosthodontics,
University of Louisville Dental School

1999-present
Associate in Radiation Oncology,
University of Louisville School of Medicine

1999-present
Adjunct Professor, Maxillofacial Prosthetics,
Tufts University School of Dental Medicine, Boston

2000-present
Member,
James Graham Brown Cancer Center

Selected Awards and Professional Honors

1982
Phi Delta Honorary Prosthodontic Fraternity

1984
Omicron Kappa Upsilon

1987
Post Graduate Distinguished Teaching Award, ULSD

1987-1988
One Year Sabbatical
University of Louisville

1990
Fellow, American College of Prosthodontics

1992
Fellow, American Academy of Maxillofacial Prosthetics

1992
Beta Delta Honorary Fraternity

1994
Sigma Xi Honorary Fraternity

1995
Fellow, American College of Dentists

1996
Scholarship, Research Award, Dental School

1989-1997
Editorial Review Board-Implant Dentistry, Williams & Wilkins

Research Interest

Clinical Studies

Amgen – Phase 3 randomized, double-blind, placebo controlled study to evaluate the efficiency and safety of weekly doses of Palifermin (Rhukgf) for the reduction of oral mucositis in subjects with advanced head and neck cancer receiving radiotherapy and concurrent chemotherapy. Principal Investigator

Serenex – A Phase 2 randomized, double-masked placebo controlled study to evaluate the efficiency of SNX-1012 in reducing the duration and severity of ulcerative oral mucositis in patients receiving cytotoxic chemotherapy for colorectal and breast cancer. Co-Principal Investigator

Sonfi Aventis – Phase III randomized trial of concomitant radiation cisplatin and tirapazamine (SR259075) versus concomitant radiation and cisplatin in patients with advanced head-and-neck cancer. Sub-Investigator

Dental School Research Projects

1. Evolution of imaging and care for head-and-neck cancer patients in a representative U.S. Cancer Center

2. Cone Beam CT isolation of calcifications in the maxillofacial and cervical soft tissues: A retrospective analysis.

Publications

Farman AG, Farman TT, Khan Z, Carter LC, Freidlander AH. The role of the dentist in detection of carotid atherosclorosis. J Dental Assoc S Africa 56:549-53, 2001

Kiat-amnuay S, Gettleman L, Khan Z, Goldsmith J. Effect of adhesive retention of maxillofacial prosthesis. Part 2: Time and reapplication effects. J Prosthetic Dentistry 85(5):438-41, 2001

Kiat-amnuay S, Gettleman L, Khan Z, Goldsmith J. Effect of adhesive retention on maxillofacial prosthesis, Part 1: Skin dressings and solvent removers. Journal of Prosthetic Dentistry, 84(3):335-40, 2000

Kiat-amnuay S, Khan Z, Gettleman L. Overdenture retention of four resilient liners over an implant bar. J Prosthetic Dentistry 81(5):568-73, 1999

Kiat-amnuay S, Trekol M, Cron C, Khan Z, Gettleman L. Simplified methods for fabricating tissue supported implant retained overdentures with retention from resilient liners. J Prosthetic Dentistry 82(2):242-45, 1999

Vivino F, Al-Hashimi I, Khan Z, LeVegue F, Salisbury P, Tran-Johnson T, Muscoplat C, Trivedi M, Goldlust B, Gallagher S. Oral pilocarpaine Hcl for treatment of symptoms of dry mouth and dry eyes connected with Sjogren’s syndrome - a controlled multicenter fixed dose trail. Arch Internal Med 159:174-81, 1999

Khan Z. Jacobson CS. Oral pilocarpine Hcl for post-irradiation xerostomia in patients with head and neck cancer. Proceedings of First International Congress on Maxillofacial Prosthetics Vol.1(1):274-77, 1994

Khan Z. Dental Oncology and Maxillofacial Prosthesis, Chapter: Novak-Contemporary Dental Assisting, Mosby, 1999