Hong Ye, PhD
Research Program
Structural Biology
Education Research and Professional Experience 1996-1998 1998-2003 Selected Awards and Professional Honors 1995-1998 2000-2002 2002-2003
B.S., Xiamen University, Xiamen, China, Cell Biology, 1987-1991
Ph.D., Keele University, Keele, UK, Biophysics, 1995-1998
Postdoctoral Fellow, Weill Medical College, Cornell University, New York, Biochemistry, 1998-2003
1991-1995
Assistant Researcher, Institute of Biophysics, Chinese Academy of Science, China
Teaching Assistant, Department of Physics, Keele University, UK
Postdoctoral Associate, Department of Biochemistry, Weill Medical College Cornell University
1995-1998
Departmental Research Studentship
Overseas Research Students Awards
Charles H. Revson Foundation fellowship
Keck Program Postdoctoral Fellow
Research Interest Structural and functional studies of signal transduction; X-ray crystallography.
The research in my laboratory is focused at understanding the structural and molecular mechanism of Notch signaling regulation primarily with X-ray crystallography combined with a variety of biophysical and biochemical methods. We are interested in the activation and regulatory processes involving different proteins, and we use thermodynamics as well as structural methods to define the interactions.
Publications Shotton MW, Pope LH, Forsyth VT, Denny R, Langan P, Ye H, Boote C. New developments in instruments forX-ray and neutron diffraction experiments. J Appl Crystallography 31:758, 1998
Ye H, Park YC, Kreishman M, Kieff E, Wu H. The structural basis for the recognition of diverse receptorsequences by TRAF2. Molecular Cell 4:321-30, 1999
Wu H, Park YC, Ye H, Tong L. Structure studies of human TRAF2. Cold Spring Harbor: Symposia onQuantitative Biology. Signaling and Gene Expression in the Immune System, 64:541-9, 1999
Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H. A novel mechanism of TRAF signalingrevealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell 101:777-87, 2000
Ye H, Wu H. Thermodynamic characterization of the interaction between TRAF2 and receptor peptides byisothermal titration calorimetry. Proc Natl Acad Sci USA 97:8961-6, 2000
Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H. Distinct molecular mechanism for initiating TRAF6 signaling. Nature 418:443-7, 2002
Ye H, Cande C, Stephanou N, Gurbuxani S, Larochette N, Daugas E, Garrido C, Kroemer G, Wu H. DNA binding as a structural requirement for apoptogenic action of AIF. Nature Struct Biol 9(9):680-4, 2002
Ye H, Cirilli M, Wu H. The use of genetic methods and diffraction data analysis in the crystallization of the TRAF domain of human TRAF6. Acta Cryst D 58:1886-8, 2002
Chung J, Park YC, Ye H, Wu H. All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Sci 115(4):679-88, 2002
Chung J, Park YC, Ye H, Wu H. TNF receptor associated factors. In: Cytokine Signaling Handbook, 2003
Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS. RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. J Biol Chem 279(23):24794-802, 2004.
Ye H, Chen TC, Xu X, Pennycooke M, Wu H, Steegborn C. Crystal structure of the putative adapter protein MTH1859. J Struct Biol 148(2):251-6, 2004.
Ye H, Maurizio C, Wu H. The use of genetic methods and diffraction data analysis in the crystallization of the TRAF domain of human TRAF6. Acta Cryst. in press.