Janina Ratajczak, MD, PhD
Research Program
Developmental Biology
Education 1982 - 1983 1983 - 1990 1991 - 1998 1998 - 2001 2002 - Present 2002 - Present
M.D., Pomeranian School of Medicine, Szczecin, Poland, Medicine, 1982
Ph.D., Medical Postgraduate Center, Warsaw, Poland, Exp. Hematology, 1995
Research and Professional Experience
Internship
Assistant in Department of Rheumatology, Regional Hospital - Szczecin.
Postdoctodal Fellow, Department of Pathology, University of Pennsylvania, Philadelphia.
Research Specialist, Department of Medicine, Division Hematology/Oncology, University of Pennsylvania, Philadelphia, PA.
Assistant Professor, Department of Medicine, University of Louisville, Louisville, KY
Associate Scientist, James Graham Brown Cancer Center, University of Louisville
Research Interest
Publications Majka M, Ratajczak J, Kowalska MA, Ratajczak MZ. Binding of stromal derived factor-1a (SDF-1a) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), and serine/threonine kinase AKT. Eur J Haematol 64:164-72, 2000 Song WJ, Sullivan MG, Legare RD, Hutchins S, Tan X, Kurfin D, Ratajczak J, Resebde IC, Hock R, Loh M, Felix C, Roy DC, Busque L, Kurnit D, Willman C, Gewirtz AM, Speck NA, Busweller JH, Li FP, Gradiner K, Poncz M, Maris JM, Gilliland DG. Haploinsufficiency of CFBA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukemia. Nature Gen 23:166-75, 1999 Majka M, Ratajczak J, Lee B, Honczarenko M, Douglas R, Kowalska MA, Silberstein L, Gewirtz AM, Ratajczak MZ. The role of HIV related chemokine receptors and chemokines in human erythropoiesis in vitro. Stem Cells 18:128-38, 2000 Pertussini E, Ratajczak J, Majka M, Vaughan D, Ratajczak M.Z, Gewirtz AM. Investigating the platelet sparing mechanism of Paclitaxel/Carboplatin combination chemotherapy. Blood 97:638-44, 2000 Majka M, Ratajczak J, Baj M, Kijowski J, Reca R, Kubiczek K, Ratajczak MZ. B iological significance of che-mokine receptors expression by normal human megkaryoblasts. Folia Histochem Cytobiol 39:235-44, 2001 Ratajczak J, Majka M, Kijowski J, Baj M, Pan ZK, Marquez LA, Janowska-Wieczorek A, Ratajczak MZ. Biological significance of MAPK, AKT and JAK-STAT protein activation by various erythropoietic factors in normal human early erythroid cells. Br J Haematol 115:195-204, 2001 Luger SM, O’Brien SG, Ratajczak J, Ratajczak MZ, Mick R, Stadmauer EA, Nowell PC, Goldman JM, Gewirtz AM. Oligodeoxynucleotide-mediated inhibition of c-myb gene expression in autografted bone marrow: a pilot study. Blood 99:1150-58, 2002 Majka M, Ratajczak J, Villaire G, Kubiczek K, Marquez LA, Janowska-Wieczorek A, Ratajczak MZ. Thrombo-poietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT and STAT proteins in normal human CD34+ cells, megakaryocytes and platelets. Exp Hematol 30:751-60, 2002 Ratajczak J, Kijowski J, Majka M, Jankowski K, Reca R, Ratajczak MZ. Biological significance of the different erythropoietic factors secreted by normal human eraly erythroid cells. Leuk Lymphoma 44(5):767-74, 2003 Rozmyslowicz T, Majka M, Kijowski J, Murphy SL, O’Connover D, Poncz M, Ratajczak J, Gaulton GN, Ratajczak MZ. Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS 17:33-42, 2003 Reca R, Mastellos D, Majka M, Marquez L, Ratajczak J, Franchini S, Glodek A, Honczarenko M, Spruce LA, Janowska-Wieczorek A, Lambris JD, Ratajczak MZ. Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells and C3a enhances homing-related responses of early hematopoietic cells to SDF-1. Blood 101:3784-93, 2003 Ratajczak J, Kucia M, Reca R, Zhang J, Machalinski B, Ratajczak MZ. Quiescent CD34+ early er