Shin-je J Ghim, PhD
Research Program
Tumor Immunobiology
Education B.A., Korea University, Food Science, 1980 1987 1988 1988 1989 1989 1989-1992 1992-1993 1993-2000 2000-2002 2002-present Selected Awards and Professional Honors
2006-present
M.A., Ajou University, Chemical Engineering, 1983
D.E.A., Lyon I University, Microbiology, 1985
Ph.D.,Lyon I University, Microbiology, 1989
Research and Professional Experience
1987
Electron Microscopy, Pasteur Institute, Paris, France
Cellular Genetics and Biology, Pasteur Institute, Paris, France
Isolation of Infectious Virologic Agents, Pasteur Institute, Lyon, France
Medical Virology, Pasteur Institute, Paris, France (Diploma)
Genetic Engineering, Pasteur Institute, Paris, France
Bacteriology, Pasteur Institute, Paris, France (Diploma)
Postdoctoral fellow, Department of Pathology, Georgetown University School of Medicine
Research Associate, Department of Pathology, Georgetown University School of Medicine
Assistant Professor, Department of Pathology, Georgetown University School of Medicine
Associate Director, Cervical Cancer Research Center, West Penn Hospital
Assistant Professor and Associate Scientist, Brown Cancer Center, University of Louisville
1993-2000
Member, Lombardi Cancer Center
2000
Member Intragency/Ocenaria Manatee Working Group
Member, Scientific Advisory Committee, Institute Pasteur - Korea
Presentation Academy Tower Award for Women Leaders in Science and Health Care
Champion 4 Her Award, University of Louisville, KY
2008
1st Mary Breckenridge Pioneer in Women's Health Award, Kentucky Commission on Women
Research Interest
The Jenson/Ghim laboratory (4D, BCC) is a translational, immunology laboratory that is working on humoral responses to prevent infection by papillomavirus. The laboratory is best known for production of papillomavirus vaccines, some of which have been patented and licensed to MedImmune/Smith Kline Beecham.
Dr. Ghim, who graduated from Claude Bernard-Lyon in France, is a molecular virologist and immunologist who has produced recombinant, prophylactic vaccines against more than 10 animal and human papillomaviruses. She has used the vaccine as substrate for several seroepidemiology studies using ELISA. She was largely responsible for developing the COPV animal model for vaccinating against cervical cancer. At present Dr. Ghim is identifying PV from and preparing vaccines for endangered species such as the manatee and snow leopard. She has been working almost a decade on expression of recombinant PV vaccines in tobacco plants. Although prophylactic PV vaccines have not as yet been produced in genetically engineered tobacco, her work at the Brown Cancer Center has provided for a collaboration to be undertaken with Large Scale Biology Corporation to develop recombinant antibodies that neutralize human papillomavirus virions by using the LSBC tobacco mosaic virus platform system designed for high output agripharmaceuticals.
Publications
Ghim, S, Newsome J, Bell J, Sundberg JP, Schlegel R, Jenson AB. Spontaneously regressing oral papillomas induce systemic antibodies that neutralize canine oral papillomavirus. Exp Mol Pathol 68:147-51, 2000
Jenson AB, Geyer S, Sundberg JP, Ghim S. Human papillomavirus and skin cancer. J Invest Dermatol 6:203-6, 2001
Ghim S, Sundberg JP, Delgado G, Jenson DP. The pathogenesis of advanced cervical cancer provides the basis for an empirical therapeutic vaccine. J. Exp Molec Pathol 71(3):181-85, 2001
Gregory D, Bossart GD, Ewing RY, Lowe M, Sweat M, Decker SJ, Walsh CJ, Ghim S, Jenson, AB. Viral Papillomatosis in Florida manatees (Trichechus manatus latirostris). Exp Mol Pathol 72:37-48, 2002
Ghim S, Basu PS, Jenson A. Cervical cancer: Etiology, pathogenesis, treatment, and future caccines. Asian Pac J Cancer Prev 3:207-14, 2002
Ghim,S, Delius H, Rector A, Sundburg JP, Jenson AB, van Ranst M. Equine papillomavirus type 1: complete nucleotide sequence and characterization of recombinant virus-like particles composed of the EcPV-1 L1 major capsid protein. Biochem Biophys Res Commun 324:1108-15. 2004
Recor A, Bossart GD, Ghim S, Sundberg JP, Jenson AP, van Ranst M. Characterization of a novel close-to-root papillomavirus from a Florida manatee by using multiply primed rolling-circle amplification: Trichechus manatus latirostris papillomavirus type 1. J Virol 78:12698-702. 2004
Rehtanz M, Ghim SJ, Rector A, Van Ranst M, Fair PA, Bossart GD, Jenson AB. Isolation and characterization of the first American bottlenose dolphin papillomavirus: Tursiops truncatus papillomavirus type 2. J Gen Virol 87(Pt 12):3559-65, 2006
Rector A, Lemey P, Tachezy R, Mostmans S, Ghim SJ, Van Doorslaer K, Roelke M, Bush M, Montali RJ, Joslin J, Burk RD, Jenson AB, Sundberg JP, Shapiro B, Van Ranst M. Ancient papillomavirus-host co-speciation in Felidae. Genome Biol 8(4):R57, 2007
Van Doorslaer K, Rector A, Jenson AB, Sundberg JP, Van Ranst M, Ghim SJ. Complete genomic characterization of a murine papillomavirus isolated from papillomatous lesions of a European harvest mouse (Micromys minutus). J Gen Virol 88(Pt 5):1484-8, 2007
Rehtanz M, Bossart GD, Doescher B, Rector A, Van Ranst M, Fair PA, Jenson AB, Ghim SJ. Bottlenose dolphin (Tursiops truncatus) papillomaviruses: Vaccine antigen candidates and screening test development. Vet Microbiol 2008 Jul 4. [Epub ahead of print]
Rector A, Stevens H, Lacave G, Lemey P, Mostmans S, Salbany A, Vos M, VanDoorslaer K, Ghim SJ, Rehtanz M, Bossart GD, Jenson AB, Van Ranst M. Genomic characterization of novel dolphin papillomaviruses provides indications for recombination within the Papillomaviridae. Virology 378(1):151-61, 2008